产品编号：HFZ5FC-050
市 场 价：¥3900.00
场 地：美国(厂家直采)
联系QQ：1570468124
电话号码：4000-520-616
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info@ebiomall.com
商品介绍
| Source | CHO cells | M.W. | CAS No. | ||
|---|---|---|---|---|---|
| Structural Info | |||||
| Formulation | Lyophilized in sterile filtered solution of PBS. | ||||
| Reconstitution | Before reconstitution, abrief spin is recommend to drive down any material dislodged from the bottom ofthe tube. The lyophilized protein shouldbe reconstituted in sterile H2O to a desired concentration. | ||||
| Stability | The lyophilized protein isstable for at least one year if stored at -80 °C. Reconstituted protein is stable forat least four weeks at 4 °C, but should be stored in aliquots at -80°C for longer term. Avoidrepeated freeze and thaw. | ||||
| Purity | Greater than 95% by SDS-PAGE analysis | ||||
| Biological Activity | The activity was determined by using a TCF reporter gene assay in cultured human cells.The IC50 ranges from 100 - 200 ng/ml in the inhibition of 100 ng/mL WNT-3a activity. | ||||
| Country of Origin | USA | ||||
Frizzled-5 is one of the 10 mammalian Frizzled receptors for WNTproteins. The extracellular cycteine rich domain of Frizzleds bind toWNTs with nM affinity. When supplied as recombinant protein, thisextracellular domain of Frizzled-5 acts as a soluble receptor, blocking thebinding of WNTs to Frizzled on the cells.
StemRD’s Frizzled-5 extracellular domain protein is fused to theN-terminus of the Fc domain of human IgG1. This fusion allows stabilizationof the protein in vitro and in vivo and dimerization of the recombinant proteinrendering high-affinity binding to WNTs. A similar protein, Frizzled-8 Fc fusion, has been used byGenentech scientists to show anti-tumor effect of WNT blockade in animal models(DeAlmeida VI et al, Cancer Res. 2007, 67:5371).
Expression is from CHO cells cultured in serum-free and protein-freemedium. Purification of the fusionprotein from conditioned culture medium is performed using protein Achromatography.
Frizzled-5 Fc fusion, human recombinant
品牌介绍
StemRD 是美国一家聚焦于尖端干细胞研究的公司，拥有蛋白表达和纯化方面的专利技术，使StemRD能够保证高效的生产那些用传统方法很难得到的重要干细胞因子。StemRD 拥有被美国FDA认证的可用于GMP生产治疗型多肽的设施。StemRD的实验室也拥有包括组织培养、细胞处理、超离心、超过滤、FPLC、HPLC和LC/MS等一系列先进设备。
公司介绍
产品分类
销售排行
Stemrd/LIF, mouse/250 µg/LIF-250
$1399.00
Stemrd/WNT-5a, mouse/25 µg/W5A-M-025
$1145.00
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